Authors: Xiaomei Niu, Mehdi Nouraie, Andrew Campbell, Sohail Rana, Caterina P. Minniti, Craig Sable, Deepika Darbari, Niti Dham, N. Scott Reading, Josef T. Prchal, Gregory J. Kato, Mark T. Gladwin, Oswaldo L. Castro, Victor R. Gordeuk
DOI: 10.1371/journal.pone.0007956
Abstract Summary
Elevated levels of PDGF-BB and interleukin-6, along with hemolysis markers, are linked to increased pulmonary hypertension risk in young sickle cell patients, while higher VEGF appears protective. These findings in 237 children suggest angiogenic and inflammatory pathways play key roles in disease progression, identifying at-risk patients who may benefit from targeted monitoring.
Why Brain? ðŸ§
Study identifies blood markers linked to pulmonary hypertension risk in children with sickle cell disease, revealing PDGF-BB and IL-6 increase risk while VEGF may be protective, potentially enabling earlier intervention.
License: CC0 (Public Domain).
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
