Sunday, October 19, 2025

Visualization of Transepithelial Passage of the Immunogenic 33-Residue Peptide from α-2 Gliadin in Gluten-Sensitive Macaques

Authors: Kaushiki Mazumdar, Xavier Alvarez, Juan T. Borda, Jason Dufour, Edith Martin, Michael T. Bethune, Chaitan Khosla, Karol Sestak

DOI: 10.1371/journal.pone.0010228

Abstract Summary

Researchers developed a rhesus macaque model that closely mimics human celiac disease, showing similar intestinal damage, antibody responses, and “leaky gut” when exposed to gluten. This breakthrough provides a valuable tool for studying celiac disease mechanisms and intestinal permeability.

Why Brain? 🧠

Researchers developed a rhesus macaque model that mimics human celiac disease, showing how toxic gluten peptides cross intestinal barriers. This breakthrough provides a valuable animal model for studying intestinal permeability and gluten sensitivity mechanisms.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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