Authors: Nguyen Thi Khanh Nhu, Ha Vinh, Tran Vu Thieu Nga, Richard Stabler, Pham Thanh Duy, Le Thi Minh Vien, H. Rogier van Doorn, Ana Cerdeño-Tárraga, Nicholas Thomson, James Campbell, Nguyen Van Minh Hoang, Tran Thi Thu Nga, Pham Van Minh, Cao Thu Thuy, Brendan Wren, Jeremy Farrar, Stephen Baker
DOI: 10.1371/journal.pntd.0000702
Abstract Summary
Two CTX-M beta-lactamase genes are spreading among Shigella bacteria in Vietnamese children, carried on simple conjugative plasmids that transfer easily between bacteria. This resistance threatens third-generation cephalosporins, commonly used empiric antibiotics in Ho Chi Minh City, which should no longer be considered for dysentery treatment in this setting.
Why Brain? 🧠
CTX-M resistance genes spread rapidly in Shigella in Vietnam via simple plasmids, rendering commonly-used third-generation cephalosporins ineffective for treating dysentery in this region.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
