Authors: Nat F Brown, Bruce A Vallance, Brian K Coombes, Yanet Valdez, Bryan A Coburn, B. Brett Finlay
DOI: 10.1371/journal.ppat.0010032
Abstract Summary
New research reveals that Salmonella activates its key virulence system (SPI-2) much earlier than previously thought – while still in the intestinal lumen, before invading tissue. This early activation may help the pathogen prepare for survival within immune cells during systemic infection.
Why Brain? ðŸ§
New research reveals Salmonella activates its key virulence system SPI-2 before invading intestinal tissue, not after as previously thought. This early activation prepares the bacteria to survive inside immune cells, offering insights for developing better treatments against typhoid-like infections.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
