Authors: Sara K. Lindén, Yong H. Sheng, Alison L. Every, Kim M. Miles, Emma C. Skoog, Timothy H. J. Florin, Philip Sutton, Michael A. McGuckin
DOI: 10.1371/journal.ppat.1000617
Abstract Summary
New research reveals MUC1, a cell-surface mucin, protects gastric cells from H. pylori infection through dual mechanisms: blocking bacterial attachment via steric hindrance and acting as a “releasable decoy” when bacteria bind to it. The study shows H. pylori adhesins trigger MUC1 shedding, and MUC1 deficiency increases cell death in both lab and mouse models.
Why Brain? 🧠
MUC1 mucin protects stomach lining from H. pylori infection through dual mechanisms: physically blocking bacterial attachment and acting as a decoy that sheds from cells, reducing bacterial adhesion and cell death.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
