Saturday, October 18, 2025

Early-Life Family Structure and Microbially Induced Cancer Risk

Authors: Martin J Blaser, Abraham Nomura, James Lee, Grant N Stemmerman, Guillermo I Perez-Perez

DOI: 10.1371/journal.pmed.0040007

Abstract Summary

Early-life family size significantly impacts gastric cancer risk decades later in men infected with H. pylori. A 28-year study of Japanese-American men found those from families with 7+ siblings had double the cancer risk compared to smaller families (1-3 siblings). This reveals how childhood social environment influences microbial cancer development 50-80 years later.

Why Brain? 🧠

Large sibship size and higher birth order in childhood significantly increase gastric cancer risk decades later in H. pylori-infected men, revealing how early-life social factors influence cancer development.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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