Authors: Pljakic E, Delic E, Corovic I, Maksic M, Radojevic D, Stanisavljevic I, Mladenovic V, Nikolic T, Suljic L, Licina EC, Vucelj S, Sagdati S, Corovic K, Igrutinovic N, Urakovic N, Plojovic H, Habibovic S, Habibovic A, Popovic D, Nikolic M, Jovanovic M.
DOI: 10.3390/biomedicines13112618
Abstract Summary
Chemerin, an adipokine with immunometabolic functions, plays dual protective and pathogenic roles across the GI tract. It promotes immune tolerance and invasion in upper GI cancers, serves as a biomarker in pancreatic disease, contributes to liver disease progression while showing tumor-suppressive potential in hepatocellular carcinoma, and has context-dependent effects in IBD. These findings highlight chemerin as a versatile regulator linking metabolism, inflammation, and GI malignancyโoffering promise for biomarker and therapeutic development.
Why Brain? ๐ง
Chemerin, an adipokine with immune and metabolic functions, plays dual roles in GI diseasesโfrom promoting cancer invasion in esophagus and stomach to protecting against liver tumors and modulating inflammation in IBD.
Study Limitations:
Study limitations were not specified in the abstract.
License: cc by.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
