CD4 + CD25 + FOXP3 + Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

Authors: Sarah L. Clarke, Gareth J. Betts, Andrea Plant, Kate L. Wright, Tariq M. El-Shanawany, Richard Harrop, Jared Torkington, Brian I. Rees, Geraint T. Williams, Awen M. Gallimore, Andrew J. Godkin

DOI: 10.1371/journal.pone.0000129

Abstract Summary

Regulatory T cells (Treg) are elevated in colorectal cancer patients’ blood and lymph nodes compared to healthy controls. These Treg suppress immune responses against tumor antigens—when removed, anti-tumor immunity is restored. Findings suggest that targeting Treg could boost cancer immunotherapy effectiveness.

Why Brain? 🧠

Regulatory T cells are elevated in colorectal cancer patients and suppress immune responses against tumor antigens. Removing these cells restores anti-tumor immunity, suggesting new immunotherapy strategies.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.