Friday, February 20, 2026

An overview of paediatric autoimmune and genetic cholestatic liver disease for the adult physician.

Authors: Bains V, Joshi D.

DOI: 10.1016/j.clinme.2025.100533

Abstract Summary

More children with chronic liver diseases are surviving into adulthood, requiring adult physicians to understand conditions like autoimmune hepatitis, sclerosing cholangitis, and cholestatic disorders. Many patients have undergone transplants and need lifelong immunosuppression. Comprehensive care must address extra-hepatic complications, metabolic issues, and mental health for optimal outcomes.

Why Brain? ๐Ÿง 

Rare pediatric liver diseases now reach adulthood due to improved survival. Adult physicians need expertise in autoimmune and genetic cholestatic conditions to manage complications and transitions.

Study Limitations:

Study limitations were not specified in the abstract.

License: cc by.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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