Authors: Scheier TC, De Gouveia K, Engel ME, Hohlfeld AS, Cen A, Berhe A, Fan S, Li J, Elliott S, Ford N, Meintjes G, Mertz D, Eikelboom J, Wasserman S.
DOI: 10.1097/qad.0000000000004431
Abstract Summary
People with advanced HIV disease (CD4 โค200 cells/mmยณ) in sub-Saharan Africa face alarming mortality rates: 12% die within one year, rising to 20% for those with CD4 โค50. Most deaths occur in the first three months. This meta-analysis of 313,362 patients highlights urgent needs for early CD4 testing and improved interventions.
Why Brain? ๐ง
Adults with advanced HIV in sub-Saharan Africa face 12-20% one-year mortality despite treatment, with most deaths in first three months, highlighting urgent need for early detection and improved care.
Study Limitations:
Substantial heterogeneity was present across studies.
High risk of bias in 18 of 36 included studies.
License: cc by.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
