Authors: Miyuki Suzawa, Holly A. Ingraham
DOI: 10.1371/journal.pone.0002117
Abstract Summary
Atrazine, a common US herbicide, disrupts reproductive hormones in zebrafish at environmentally relevant concentrations, increasing aromatase expression and skewing sex ratios toward females. The chemical activates SF-1 nuclear receptors through phosphorylation and cAMP signaling rather than direct binding, affecting genes crucial for steroid synthesis and reproduction in both fish and mammalian cells.
Why Brain? ๐ง
Atrazine herbicide disrupts hormone systems in fish and mammals by activating reproductive genes through nuclear receptors and cell signaling pathways, potentially explaining reproductive abnormalities in wildlife.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
