Authors: Katrin Biedasek, Janin Andres, Knut Mai, Stephanie Adams, Simone Spuler, Jens Fielitz, Joachim Spranger
DOI: 10.1371/journal.pone.0016674
Abstract Summary
Researchers found that the enzyme 11β-HSD1, which converts inactive cortisone to active cortisol in muscle cells, plays a key role in glucocorticoid-induced muscle wasting. Blocking this enzyme with an inhibitor completely prevented cortisone-triggered protein breakdown and suppressed genes linked to muscle atrophy. This discovery suggests 11β-HSD1 inhibitors could offer a therapeutic strategy to combat muscle loss.
Why Brain? 🧠
Blocking 11beta-HSD1 enzyme prevents steroid-induced muscle wasting by stopping protein breakdown, offering a potential therapeutic target to preserve muscle mass in patients on glucocorticoid therapy.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
