Monday, March 2, 2026

Modulation of metabolic syndrome components by oral semaglutide in hypothyroid-T2DM patients: a retrospective analysis.

Authors: Tilici DM, Costinescu RM, Paun DL, Paun SC, Guja C.

DOI: 10.25122/jml-2025-0144

Abstract Summary

Oral semaglutide shows promise for managing metabolic syndrome in patients with both type 2 diabetes and hypothyroidism. In a 6-month study of 51 patients, treatment significantly improved HbA1c, BMI, blood pressure, and lipid profiles. These findings suggest semaglutide may benefit this high-risk population, though larger prospective trials are needed to confirm results.

Why Brain? ๐Ÿง 

Oral semaglutide improved HbA1c, BMI, blood pressure, and lipids in hypothyroid-T2DM patients, suggesting benefit in this high-risk, understudied metabolic syndrome population.

Study Limitations:

Single-center retrospective cohort study
Small sample size of 51 adult patients
Observational study design

License: cc by.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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