Authors: Ping Jiao, Bin Feng, Haiyan Xu
DOI: 10.1371/journal.pone.0041168
Abstract Summary
New research reveals how MKP-3 protein regulates blood sugar by activating FOXO1 in liver cells. Scientists identified specific protein regions essential for their interaction and found that MKP-3’s enzyme activity is crucial for glucose production. Importantly, constitutively active FOXO1 can override the blood sugar-lowering effects of reduced MKP-3, suggesting MKP-3 inhibition may offer a therapeutic target for diabetes treatment.
Why Brain? ðŸ§
Study identifies how MKP-3 protein interacts with FOXO1 to control liver glucose production, revealing potential therapeutic targets for managing blood sugar in obesity and diabetes.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
