Elevated serum chromogranin A levels are independently associated with metabolic and inflammatory disturbances in polycystic ovary syndrome.

Authors: Alarslan P, Doruk M.

DOI: 10.3389/fendo.2025.1682910

Abstract Summary

Chromogranin A (CgA), a neuroendocrine protein, shows promise as a novel biomarker for PCOS. This study found significantly elevated serum CgA levels in 75 PCOS patients versus controls (935 vs. 642 pg/mL). Higher CgA correlated independently with obesity, insulin resistance, and inflammation—key metabolic risk factors in PCOS. These findings suggest CgA could help stratify metabolic risk in PCOS patients.

Why Brain? 🧠

Chromogranin A levels are significantly elevated in PCOS patients and independently linked to obesity, insulin resistance, and inflammation, suggesting potential as a novel biomarker for metabolic risk assessment.

License: CC BY.

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