Authors: Krzystek Ł, Sagan KP, Andrysiak-Mamos E, Retfiński S, Buć K, Marczak W, Brzeska A, Patalong-Wójcik M, Żochowska E, Dąbkowski K, Syrenicz A.
DOI: 10.3389/fendo.2025.1700273
Abstract Summary
A 74-year-old woman with severe Cushing’s syndrome from an ACTH-secreting pancreatic tumor was successfully treated using a two-step approach. Initially stabilized with IV etomidate, she then received oral osilodrostat, which normalized her cortisol levels and reversed debilitating symptoms including cognitive decline and muscle weakness. After 19 months, minimally invasive ethanol ablation eliminated the tumor, allowing treatment discontinuation.
Why Brain? 🧠
Novel treatment approach for rare ectopic Cushing’s syndrome: dual drug therapy normalized severe hormone excess, followed by minimally invasive tumor ablation, offering hope for high-risk surgical patients.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
