Authors: Marie Chintinne, Geert Stangé, Bart Denys, Zhidong Ling, Peter In ‘t Veld, Daniel Pipeleers
DOI: 10.1371/journal.pone.0043959
Abstract Summary
Pancreatic duct ligation in mice triggers formation of new small beta cell clusters with increased proliferation, but doesn’t boost total beta cell numbers. Direct cell counting proved more accurate than mass measurements for detecting regeneration. Similar proliferation patterns appeared in inflamed human pancreatic tissue, suggesting potential therapeutic targets for diabetes.
Why Brain? 🧠
PDL surgery triggers formation of new small insulin-producing cell clusters with increased proliferation, but doesn’t increase total beta cell count, highlighting the need for direct cell counting over mass measurements.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
