Authors: Nemr R, Zidi S, Echtay A, Racoubian E, Beydoun N, Almawi WY.
DOI: 10.3389/fendo.2025.1738873
Abstract Summary
Study reveals that specific APOE gene variants, particularly ε4-containing genotypes, significantly increase diabetic nerve damage risk in type 2 diabetes patients—independent of blood sugar control. The ε2 and ε4 variants showed 1.6-1.9x higher neuropathy odds through distinct lipid metabolism pathways, while ε3/ε3 was protective. Findings suggest APOE genotyping could enhance personalized risk assessment for diabetic neuropathy.
Why Brain? 🧠
ApoE gene variants, particularly ε4, increase diabetic nerve damage risk in type 2 diabetes patients independent of blood sugar control, suggesting lipid metabolism plays a key role in neuropathy development.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
