Neurological Disorders
Granular Assembly of α-Synuclein Leading to the Accelerated Amyloid Fibril Formation with Shear Stress
Authors: Ghibom Bhak, Jung-Ho Lee, Ji-Sook Hahn, Seung R. Paik DOI: 10.1371/journal.pone.0004177 Abstract Summary Researchers discovered that α-synuclein, the protein...
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Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells
Authors: Madalina Rujoi, Nina H. Pipalia, Frederick R. Maxfield DOI: 10.1371/journal.pone.0012788 Abstract Summary Researchers identified compounds that reduce cholesterol buildup...
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Mutants of GABA Transaminase (POP2) Suppress the Severe Phenotype of succinic semialdehyde dehydrogenase ( ssadh ) Mutants in Arabidopsis
Authors: Frank Ludewig, Anke Hüser, Hillel Fromm, Linda Beauclair, Nicolas Bouché DOI: 10.1371/journal.pone.0003383 Abstract Summary Researchers found that blocking a...
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Dissociated Fear and Spatial Learning in Mice with Deficiency of Ataxin-2
Authors: Duong P. Huynh, Marwan Maalouf, Alcino J. Silva, Felix E. Schweizer, Stefan M. Pulst DOI: 10.1371/journal.pone.0006235 Abstract Summary Ataxin-2...
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MRI Pattern Recognition in Multiple Sclerosis Normal-Appearing Brain Areas
Authors: Martin Weygandt, Kerstin Hackmack, Caspar Pfüller, Judith Bellmann–Strobl, Friedemann Paul, Frauke Zipp, John–Dylan Haynes DOI: 10.1371/journal.pone.0021138 Abstract Summary Machine...
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Evidence for Gender-Specific Transcriptional Profiles of Nigral Dopamine Neurons in Parkinson Disease
Authors: Filip Simunovic, Ming Yi, Yulei Wang, Robert Stephens, Kai C. Sonntag DOI: 10.1371/journal.pone.0008856 Abstract Summary Gene expression analysis of...
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Different Susceptibility to the Parkinson’s Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1
Authors: Nadia G. Innamorato, Agnieszka Jazwa, Ana I. Rojo, Concepción García, Javier Fernández-Ruiz, Anna Grochot–Przeczek, Anna Stachurska, Alicja Jozkowicz, Jozef...
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A Putative Alzheimer’s Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis
Authors: Zongqi Xia, Lori B. Chibnik, Bonnie I. Glanz, Maria Liguori, Joshua M. Shulman, Dong Tran, Samia J. Khoury, Tanuja...
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Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival
Authors: Abhisek Mukherjee, Diego Morales-Scheihing, Dennisse Gonzalez-Romero, Kristi Green, Giulio Taglialatela, Claudio Soto DOI: 10.1371/journal.ppat.1001138 Abstract Summary Researchers found that...
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Alzheimer’s Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome
Authors: Juliet A. Moncaster, Roberto Pineda, Robert D. Moir, Suqian Lu, Mark A. Burton, Joy G. Ghosh, Maria Ericsson, Stephanie...
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