Authors: Peter Stachon, Anna Missiou, Carina Walter, Nerea Varo, Christian Colberg, Dennis Wolf, Maike Buchner, Constantin von zur Mühlen, Katja Zirlik, Christoph Bode, Andreas Zirlik
DOI: 10.1371/journal.pone.0011589
Abstract Summary
Despite TRAF6’s role as a pro-inflammatory signaling molecule overexpressed in atherosclerotic plaques, this study found that TRAF6 deficiency in mice did not reduce plaque formation or alter plaque composition. Human blood samples also showed no correlation between TRAF6 levels and coronary heart disease severity, suggesting TRAF6’s pro- and anti-inflammatory effects balance out in atherosclerosis.
Why Brain? 🧠
Despite TRAF6’s role in inflammatory signaling, this study shows it’s not essential for atherosclerosis development in mice and doesn’t correlate with coronary disease severity in humans.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
