Authors: Sachin Gupte, Nazar Labinskyy, Rakhee Gupte, Anna Csiszar, Zoltan Ungvari, John G. Edwards
DOI: 10.1371/journal.pone.0011800
Abstract Summary
Chronic hyperglycemia triggers vascular dysfunction through NADPH oxidase-driven superoxide production, not increased enzyme expression. In diabetic rats, elevated superoxide levels impaired blood vessel relaxation—a key marker of endothelial dysfunction. Crucially, blocking superoxide with apocynin reversed this damage, suggesting NADPH oxidase activation as a therapeutic target for preventing cardiovascular complications in diabetes.
Why Brain? 🧠
Chronic hyperglycemia in diabetic rats causes vascular dysfunction through increased superoxide production via NADPH oxidase activation, not increased enzyme expression, offering new therapeutic targets.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
