Authors: Ana V. Villar, Manuel Cobo, Miguel Llano, Cecilia Montalvo, Francisco González-Vílchez, Rafael Martín-Durán, María A. Hurlé, J. Francisco Nistal
DOI: 10.1371/journal.pone.0008476
Abstract Summary
Elevated plasma TGF-β1 levels correlate with cardiac remodeling in both aortic stenosis patients and mouse models under pressure overload. The study demonstrates that circulating TGF-β1 associates with increased ventricular mass, fibrosis markers, and hypertrophic gene expression, suggesting plasma TGF-β1 may serve as a biomarker for myocardial remodeling severity.
Why Brain? 🧠
Plasma TGF-β1 levels correlate with heart muscle remodeling in aortic stenosis patients and mice, suggesting potential use as a biomarker for assessing cardiac damage severity before valve surgery.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
