Thursday, March 5, 2026

Independent Associations of Fasting Insulin, Glucose, and Glycated Haemoglobin with Stroke and Coronary Heart Disease in Older Women

Authors: Debbie A Lawlor, Abigail Fraser, Shah Ebrahim, George Davey Smith

DOI: 10.1371/journal.pmed.0040263

Abstract Summary

In older women without diabetes, insulin resistanceโ€”not blood sugar levelsโ€”emerges as the key cardiovascular risk factor. A study of 3,246 British women aged 60-79 found that elevated fasting insulin strongly predicted heart disease and stroke, while fasting glucose and HbA1c showed no association. This challenges current diagnostic focus on glucose thresholds alone.

Why Brain? ๐Ÿง 

In older women without diabetes, insulin resistanceโ€”not blood sugar levelsโ€”predicts heart disease and stroke risk, suggesting current glucose-based screening may miss at-risk individuals.

License: CC BY.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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