Sunday, November 30, 2025

Identification of a Cardiac Specific Protein Transduction Domain by In Vivo Biopanning Using a M13 Phage Peptide Display Library in Mice

Authors: Maliha Zahid, Brett E. Phillips, Sean M. Albers, Nick Giannoukakis, Simon C. Watkins, Paul D. Robbins

DOI: 10.1371/journal.pone.0012252

Abstract Summary

Researchers identified a novel peptide called CTP that specifically targets and enters heart tissue. Using phage display technology, they discovered this 12-amino acid sequence can efficiently deliver therapeutic molecules to cardiac cells while avoiding other organs like liver, brain, and skeletal muscle. CTP outperformed standard delivery methods and shows promise for heart-specific drug delivery.

Why Brain? 🧠

Researchers identified a peptide that specifically delivers therapeutic molecules to heart tissue, offering a targeted approach for cardiac drug delivery with minimal uptake by other organs.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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