Authors: Piotr Religa, Monika K. Grudzinska, Krzysztof Bojakowski, Joanna Soin, Jerzy Nozynski, Michal Zakliczynski, Zbigniew Gaciong, Marian Zembala, Cecilia Söderberg-Nauclér
DOI: 10.1371/journal.pone.0004187
Abstract Summary
New research reveals that recipient cells migrate into transplanted hearts, contributing to vessel damage. In 124 heart biopsies, host-derived smooth muscle cells correlated with rejection severity and inflammation. The protein MCP-1 drives this harmful cell migration, suggesting a potential therapeutic target.
Why Brain? 🧠
Study reveals host smooth muscle cells migrate to transplanted hearts during rejection episodes, with MCP-1 protein driving this process. Blocking MCP-1 reduced cell accumulation in mice.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
