Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease

Authors: Harry Hemingway, Peter Philipson, Ruoling Chen, Natalie K. Fitzpatrick, Jacqueline Damant, Martin Shipley, Keith R. Abrams, Santiago Moreno, Kate S. L. McAllister, Stephen Palmer, Juan Carlos Kaski, Adam D. Timmis, Aroon D. Hingorani

DOI: 10.1371/journal.pmed.1000286

Abstract Summary

A comprehensive meta-analysis of 83 studies examining C-reactive protein as a predictor in coronary disease reveals significant methodological biases across the research. These flaws prevent definitive conclusions about CRP’s clinical utility in heart disease management, highlighting the need for higher-quality prognostic studies.

Why Brain? 🧠

Meta-analysis of 83 studies reveals significant biases in C-reactive protein research for coronary disease prognosis, highlighting critical quality issues that prevent reliable clinical application.

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