Authors: John P. Bentley, Folkert W. Asselbergs, Christopher S. Coffey, Patricia R. Hebert, Jason H. Moore, Hans L. Hillege, Wiek H. van Gilst
DOI: 10.1371/journal.pone.0012757
Abstract Summary
Gene variants in the renin-angiotensin, bradykinin, and fibrinolytic systems interact to influence cardiovascular disease risk, according to a Dutch study of 8,138 participants. While most variants showed no individual effect, researchers found significant two-way interactions between specific gene pairs that affected cardiovascular outcomes, even after adjusting for traditional risk factors.
Why Brain? ðŸ§
Gene interactions from renin-angiotensin, bradykinin, and fibrinolytic systems significantly affect cardiovascular disease risk beyond individual gene effects, revealing complex biological pathways in heart disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
