Switching Multiple Sclerosis Patients with Breakthrough Disease to Second-Line Therapy
Authors: Tamara Castillo-Trivino, Ellen M. Mowry, Alberto Gajofatto, Dorothee Chabas, Elizabeth Crabtree-Hartman, Bruce A. Cree, Douglas S. Goodin, Ari J....
Saturday, December 6, 2025
A 50-Year-Old Man with Deteriorating Cognitive Function and Impaired Movement
Authors: Andrew J Larner DOI: 10.1371/journal.pmed.1000019 Abstract Summary A case study explores the diagnostic workup and treatment approach for a...
Evidence of Key Tinnitus-Related Brain Regions Documented by a Unique Combination of Manganese-Enhanced MRI and Acoustic Startle Reflex Testing
Authors: Avril Genene Holt, David Bissig, Najab Mirza, Gary Rajah, Bruce Berkowitz DOI: 10.1371/journal.pone.0014260 Abstract Summary Researchers combined behavioral testing...
Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart
Authors: Julien Vermot, Arian S. Forouhar, Michael Liebling, David Wu, Diane Plummer, Morteza Gharib, Scott E. Fraser DOI: 10.1371/journal.pbio.1000246 Abstract...
Gene Expression Signature in Peripheral Blood Detects Thoracic Aortic Aneurysm
Authors: Yulei Wang, Catalin C. Barbacioru, Dov Shiffman, Sriram Balasubramanian, Olga Iakoubova, Maryann Tranquilli, Gonzalo Albornoz, Julie Blake, Necip N....
Measuring hsCRP—An Important Part of a Comprehensive Risk Profile or a Clinically Redundant Practice?
Authors: James P. McCormack, G. Michael Allan DOI: 10.1371/journal.pmed.1000196 Abstract Summary Two medical experts explore the clinical utility and controversies...
Tumor Necrosis Factor Receptor Associated Factor 6 Is Not Required for Atherogenesis in Mice and Does Not Associate with Atherosclerosis in Humans
Authors: Peter Stachon, Anna Missiou, Carina Walter, Nerea Varo, Christian Colberg, Dennis Wolf, Maike Buchner, Constantin von zur Mühlen, Katja...
A 75-Year-Old Woman with a Hemispheric Stroke
Authors: Stavros K Kakkos, George Geroulakos DOI: 10.1371/journal.pmed.0020079 Abstract Summary Explore the essential approach to hemispheric stroke through a practical...
Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral- Therapy-Naive Patients Infected with HIV-1
Authors: Frank van Leth, Prahpan Phanuphak, Erik Stroes, Brian Gazzard, Pedro Cahn, François Raffi, Robin Wood, Mark Bloch, Christine Katlama,...
Factors Associated with Adherence to Anti-Hypertensive Treatment in Pakistan
Authors: Saman K. Hashmi, Maria B. Afridi, Kanza Abbas, Rubina A. Sajwani, Danish Saleheen, Philippe M. Frossard, Mohammad Ishaq, Aisha...