Saturday, February 21, 2026

Metformin use in gestational diabetes mellitus and neonatal outcomes: a systematic review and meta-analysis on the risk of small for gestational age.

Authors: Zhang W, Ren L, Du J, Sun R, Zhao W, Song X, Jiang S, Wang Z, Wang W.

DOI: 10.3389/fmed.2025.1737337

Abstract Summary

Metformin for gestational diabetes doesn’t increase the risk of small-for-gestational-age babies, according to a systematic review of 19 studies with over 115,000 participants. The analysis found no significant difference compared to insulin or placebo, and metformin even showed better outcomes than diet modification alone, supporting its safety profile for GDM management.

Why Brain? ๐Ÿง 

Meta-analysis of 115,192 participants shows metformin for gestational diabetes doesn’t increase risk of small-for-gestational-age newborns, supporting its safety as treatment option.

Study Limitations:

Study limitations were not specified in the abstract.

License: cc by.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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