Authors: Liu Y, Zeng X, Lyu Z, Huang D.
DOI: 10.3389/fmicb.2025.1720153
Abstract Summary
Carcinogenic microorganisms hijack the host’s ubiquitin-proteasome system to drive cancer development. HPV, HBV, HCV, EBV, and KSHV employ distinct strategies—degrading tumor suppressors, evading immune surveillance, and activating growth pathways through ubiquitin modifications. Non-viral agents like H. pylori also exploit these mechanisms. Understanding this shared strategy offers promising targets for precision cancer therapies.
Why Brain? 🧠
Carcinogenic microbes hijack cellular protein modification systems to drive cancer development, with viruses like HPV degrading tumor suppressors and evading immune detection, revealing new precision therapy targets.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
