Authors: Strauss V, Appa H, Human P, Vogt F, Hadasha W, Scherman J, Said-Hartley Q, Schneeberger Y, Bergmeister H, Conradi L, Podesser BK, Zilla P.
DOI: 10.3389/fcvm.2025.1699721
Abstract Summary
Pigs and sheep used to test transcatheter heart valves show critical anatomical differences from humans: their coronary arteries sit lower and more laterally, raising obstruction risk during valve implantation. While body weight correlates with aortic dimensions, individual variation requires CT screening for proper animal selection. Silicone casting validated against CT offers an ethical, scalable method for anatomical assessment.
Why Brain? đź§
Pigs and sheep have lower, more lateral coronary arteries than humans, risking obstruction during valve testing. CT-guided selection improves animal model accuracy for transcatheter device development.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
