Authors: Xu J, Yu W, Kang Y, Yang D, Liu Y, Bi W, Yu H, Qi B, Guo B.
DOI: 10.3389/fcell.2025.1731453
Abstract Summary
Researchers identified FGF9 as a key driver of shoulder stiffness through joint capsule fibrosis. Using RNA sequencing and mouse models, they found that FGF9 promotes fibroblast activation via the PI3K/Akt pathway. Blocking this pathway with LY294002 reduced capsule thickening and improved range of motion, suggesting a promising new therapeutic target for this painful condition.
Why Brain? ðŸ§
FGF9 drives shoulder stiffness by activating fibroblasts via PI3K/Akt pathway. Blocking this pathway reduced fibrosis and improved mobility in mice, offering a potential new treatment target.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
