Thursday, January 22, 2026

Multiorgan crosstalk in MASLD/MASH: from hepatic pathogenesis to systemic complications.

Authors: Bai W, Zhu Z.

DOI: 10.3389/fendo.2025.1720780

Abstract Summary

MASLD is now recognized as a systemic metabolic disorder, not just a liver disease. This review explores how the liver interacts with the brain, gut, and kidneys through shared inflammatory and metabolic pathways. Understanding these connections is crucial for developing comprehensive treatment strategies that target multiple organ systems rather than the liver alone.

Why Brain? 🧠

MASLD is now recognized as a systemic disease affecting multiple organs beyond the liver, requiring integrated treatment approaches that address brain, gut, and kidney complications through shared inflammatory pathways.

License: CC BY.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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