Authors: Tanabe H, Mizukami Y, Ono Y, Takei H, Tamamura N, Kobayashi Y, Takahashi K, Ando K, Ueno N, Kashima S, Tanino M, Moriichi K, Fujiya M, Okumura T.
DOI: 10.3389/fgene.2025.1668133
Abstract Summary
Researchers compared genetic mutations in colorectal tumors from familial adenomatous polyposis (FAP) patients versus sporadic cases. While APC and KRAS mutation frequencies were similar, FAP tumors showed a distinct pattern: 75% acquired a second APC mutation after inheriting one, and 10% gained a third “hit”—revealing unexpected genetic complexity in inherited colon cancer development.
Why Brain? 🧠
Study reveals FAP patients can acquire ‘three-hit’ APC mutations during colorectal cancer development, showing both inherited and acquired genetic changes drive tumor progression similarly to sporadic cases.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
