Machine learning and validation reveal that immune-related genes in systemic lupus erythematosus regulate apoptosis and cycle progression in diffuse large B-cell lymphoma.

Authors: Ruan S, Wang S, Jiang Y.

DOI: 10.3389/fmed.2025.1707913

Abstract Summary

Researchers identified CD247 as a crucial gene linking lupus (SLE) to lymphoma (DLBCL) risk. Using machine learning, they found high CD247 expression enhances anti-tumor immunity through CD8+ T cells and inhibits lymphoma cell growth while promoting cancer cell death. This discovery reveals shared immune mechanisms between the two diseases and potential therapeutic targets.

Why Brain? 🧠

Study identifies CD247 gene linking lupus to lymphoma risk, showing it regulates immune response and cancer cell death, potentially explaining why lupus patients develop this blood cancer.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.