Authors: Shitaye G, Getie M, Mekonnen Z, D’Abrosca G, Fattorusso R, Isernia C, Amuamuta A, Malgieri G.
DOI: 10.3389/fendo.2025.1737894
Abstract Summary
Long COVID is increasingly linked to new-onset diabetes, affecting both type 1 and type 2 forms. This review explores how SARS-CoV-2 may trigger diabetes through multiple mechanisms: direct pancreatic β-cell damage, inflammation, insulin resistance, and autoimmune responses. Key factors include ACE2/RAS pathway disruption and elevated inflammatory cytokines. Notably, persistent viral RNA in tissues may directly harm pancreatic islets.
Why Brain? 🧠
Long COVID is linked to new-onset diabetes through multiple mechanisms including direct pancreatic damage, inflammation, and persistent viral RNA. Understanding these pathways may help prevent metabolic complications.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
