Authors: Kim JH, Irfan M, Sreekumar S, Phimon A, Kim S, Chung S.
DOI: 10.7554/elife.105153
Abstract Summary
Researchers enhanced tooth repair by engineering dental stem cells to overexpress BDNF, a neural growth factor. In a mouse model, these modified cells significantly boosted dentin regeneration in damaged teeth. The study reveals inflammation activates the BDNF-TrkB pathway during natural tooth repair, opening new therapeutic strategies for dental regeneration.
Why Brain? ðŸ§
CRISPR-engineered dental stem cells overexpressing BDNF significantly enhance dentin regeneration in damaged teeth, offering a promising stem cell therapy approach for treating dental caries and injuries.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
