Sunday, January 18, 2026

A rare case report of prosthetic loosening secondary to diffuse non-pigmented villonodular synovitis after bilateral total knee arthroplasty.

Authors: Cai K, Yan W, Lin L, Li L, Yu H, Jiang H, Jiang H.

DOI: 10.3389/fsurg.2025.1709479

Abstract Summary

Rare case reveals synovial hyperplasia—not the typical pigmented form—as a recurring cause of knee replacement failure. A patient experienced aseptic loosening in both knees over 14 years, with each failure driven by the same benign tissue overgrowth mechanism. Revision surgery successfully stabilized both joints, demonstrating effective treatment for this uncommon complication.

Why Brain? 🧠

Rare case shows non-pigmented synovial tissue overgrowth can cause knee replacement failure in both knees over time, requiring revision surgery. Highlights unusual cause of implant loosening.

License: CC BY.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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