Primary scrotal diffuse large B-cell lymphoma with skip metastasis to the mediastinum: a case report and literature review.

Authors: Wang Z, Tang W, Xiao D, Li Y, Liang G, Zhao Z, Wu T.

DOI: 10.3389/fonc.2025.1698794

Abstract Summary

Rare case of primary scrotal lymphoma in an 81-year-old man initially mimicked testicular cancer but proved to be aggressive diffuse large B-cell lymphoma. Unusual “skip metastasis” to mediastinum without regional lymph node involvement highlighted the disease’s atypical behavior. With >90% Ki-67 index and stage IV presentation, the patient died within 3 months after refusing treatment—underscoring the critical need for early biopsy and heightened clinical suspicion when evaluating scrotal masses.

Why Brain? 🧠

Rare scrotal lymphoma case shows aggressive behavior with unusual skip metastasis pattern, emphasizing need for early biopsy and vigilance as symptoms mimic common malignancies.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.