Authors: Wang P, Liu K, Liu X, Wang W, Liu D, Wang Y, Sun S, Hu K.
DOI: 10.3389/fonc.2025.1725405
Abstract Summary
Intensified neoadjuvant radiotherapy (55-56 Gy) followed by surgery achieved impressive results in 415 rectal cancer patients: 23.9% complete pathological response and 86.5% sphincter preservation. Waiting >10 weeks between radiation and surgery improved response rates. Patients with complete response showed significantly better disease-free survival (83% vs 63%), with acceptable side effects.
Why Brain? ðŸ§
Higher-dose neoadjuvant radiotherapy for rectal cancer achieves 23.9% complete response rate with acceptable toxicity and improved survival, especially when surgery is delayed beyond 10 weeks.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
