Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell-induced pregnancy loss model.

Authors: Li G, Wang T, Tan D, Jin Y, Zhou X, Ai H, Zheng X, Ren X, Hu S, Lei C, Fu W.

DOI: 10.3389/fphar.2025.1703805

Abstract Summary

Novel PD-L1-Fc fusion protein shows promise in preventing immune-related miscarriages. In mouse models, the treatment significantly reduced abortion rates by suppressing harmful Th17 immune responses at the maternal-fetal interface. This engineered protein offers a potential new therapeutic approach for spontaneous abortion linked to immune dysfunction.

Why Brain? 🧠

Novel PD-L1 fusion protein successfully prevents miscarriage in mouse models by reducing harmful immune responses, offering a promising new immunotherapy approach for recurrent pregnancy loss in women.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.