Sunday, January 18, 2026

Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, Clonorchis sinensis

Authors: Won Gi Yoo, Dae-Won Kim, Jung-Won Ju, Pyo Yun Cho, Tae Im Kim, Shin-Hyeong Cho, Sang-Haeng Choi, Hong-Seog Park, Tong-Soo Kim, Sung-Jong Hong

DOI: 10.1371/journal.pntd.0001208

Abstract Summary

Researchers mapped gene expression across three life stages of Clonorchis sinensis, a liver fluke infecting 15 million people in Asia. The study revealed stage-specific genes: adults showed high metabolism and reproduction activity, metacercariae expressed host-adaptation genes, and eggs displayed embryonic genes. These findings illuminate how the parasite survives and may lead to new drug targets.

Why Brain? đź§ 

Study maps gene expression across life stages of liver fluke causing cancer, revealing stage-specific metabolic patterns that could lead to new drug targets for treating 15 million infected patients.

License: CC BY.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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