Sunday, January 18, 2026

Serum Penicillin G Levels Are Lower Than Expected in Adults within Two Weeks of Administration of 1.2 Million Units

Authors: Michael P. Broderick, Christian J. Hansen, Kevin L. Russell, Edward L. Kaplan, Jeffrey L. Blumer, Dennis J. Faix

DOI: 10.1371/journal.pone.0025308

Abstract Summary

Study reveals benzathine penicillin G may lose effectiveness sooner than expected. In 329 military recruits, protective blood levels dropped below therapeutic thresholds in under 2.5 weeks—much earlier than the assumed 3-4 week duration. These findings challenge current treatment protocols for streptococcal infections and warrant revised dosing guidelines.

Why Brain? 🧠

Standard benzathine penicillin injections provide protective drug levels for less than 2.5 weeks, not the expected 3-4 weeks, potentially compromising strep infection treatment and prevention strategies.

License: CC0 (Public Domain).


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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