Making Co-Enrolment Feasible for Randomised Controlled Trials in Paediatric Intensive Care

Authors: Katie Harron, Twin Lee, Tracy Ball, Quen Mok, Carrol Gamble, Duncan Macrae, Ruth Gilbert

DOI: 10.1371/journal.pone.0041791

Abstract Summary

Co-enrolling critically ill children in multiple trials simultaneously appears feasible without compromising recruitment. In a study of two pediatric intensive care trials, units that allowed co-enrollment maintained similar consent rates to single-trial approaches. Despite concerns about overwhelming parents, 49% of families consented to both studies when offered. These findings suggest co-enrollment could accelerate research delivery in PICUs.

Why Brain? 🧠

Study shows enrolling critically ill children in multiple trials simultaneously is feasible without reducing participation rates, potentially accelerating pediatric intensive care research.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.