Authors: Julia Gansler, Miriam Jaax, Silke Leiting, Bettina Appel, Andreas Greinacher, Silvia Fischer, Klaus T. Preissner
DOI: 10.1371/journal.pone.0050399
Abstract Summary
Hairpin-structured RNA and DNA molecules powerfully activate blood clotting by binding to kininogen, unlike linear nucleic acids. These stable hairpin structures resist plasma degradation and trigger prekallikrein activation. Therapeutic DNA aptamers and natural RNAs showed similar procoagulant effects, raising concerns about potential prothrombotic side effects in clinical applications.
Why Brain? ðŸ§
Hairpin-structured nucleic acids strongly activate blood clotting by binding to kininogen, suggesting therapeutic RNA/DNA aptamers may cause dangerous clotting side effects in patients.
License: CC BY.
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