Authors: Beatrice Oneda, Nadège Lods, Daniel Lottaz, Christoph Becker-Pauly, Walter Stöcker, Jeffrey Pippin, Maya Huguenin, Daniel Ambort, Hans-Peter Marti, Erwin E. Sterchi
DOI: 10.1371/journal.pone.0002278
Abstract Summary
Researchers discovered that meprinβ, a metalloendopeptidase enzyme, is expressed in kidney glomerular podocytes and may play a role in glomerular disease. The enzyme’s expression pattern changed in two experimental nephritis models, and it was identified as a potential autoantigen in Heymann nephritis. These findings suggest meprinβ could be involved in kidney disease mechanisms.
Why Brain? 🧠
Meprinβ metalloprotease is newly identified in kidney glomerular cells and shows altered expression in experimental nephritis models, suggesting its potential role as an autoantigen in glomerular disease.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
