Evaluation of the INS-1 832/13 Cell Line as a Beta-Cell Based Screening System to Assess Pollutant Effects on Beta-Cell Function

Authors: Tine L. M. Hectors, Caroline Vanparys, Anna Pereira-Fernandes, Geert A. Martens, Ronny Blust

DOI: 10.1371/journal.pone.0060030

Abstract Summary

Researchers evaluated whether INS-1 832/13 pancreatic beta-cells could serve as a screening system for environmental pollutants that disrupt metabolism and contribute to diabetes. While the cells responded appropriately to acute control compounds, they showed limited responses to common pollutants like bisphenol A. Chronic exposure tests yielded inconsistent results, suggesting this cell line lacks key characteristics for reliable pollutant screening.

Why Brain? 🧠

Study tests INS-1 832/13 beta-cells for screening environmental pollutants’ effects on diabetes risk, but finds this cell line inadequate for detecting pollutant impacts on insulin secretion after acute or chronic exposure.

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