Authors: Harald Staiger, Fausto Machicao, Norbert Stefan, Otto Tschritter, Claus Thamer, Konstantinos Kantartzis, Silke A. Schäfer, Kerstin Kirchhoff, Andreas Fritsche, Hans-Ulrich Häring
DOI: 10.1371/journal.pone.0000832
Abstract Summary
Genetic variants in SLC30A8 and HHEX genes are linked to impaired insulin secretion rather than insulin resistance in type 2 diabetes. Study of 921 subjects reveals these variants affect β-cell function, potentially making pancreatic cells more vulnerable to environmental stressors like poor diet and inactivity—key insight for understanding diabetes development.
Why Brain? 🧠
Novel genetic variants in SLC30A8 and HHEX genes increase type 2 diabetes risk by impairing insulin secretion, not insulin resistance, making pancreatic beta-cells more vulnerable to environmental stressors.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
