A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes

Authors: Shiro Maeda, Masa-aki Kobayashi, Shin-ichi Araki, Tetsuya Babazono, Barry I. Freedman, Meredith A. Bostrom, Jessica N. Cooke, Masao Toyoda, Tomoya Umezono, Lise Tarnow, Torben Hansen, Peter Gaede, Anders Jorsal, Daniel P. K. Ng, Minoru Ikeda, Toru Yanagimoto, Tatsuhiko Tsunoda, Hiroyuki Unoki, Koichi Kawai, Masahito Imanishi, Daisuke Suzuki, Hyoung Doo Shin, Kyong Soo Park, Atsunori Kashiwagi, Yasuhiko Iwamoto, Kohei Kaku, Ryuzo Kawamori, Hans-Henrik Parving, Donald W. Bowden, Oluf Pedersen, Yusuke Nakamura

DOI: 10.1371/journal.pgen.1000842

Abstract Summary

A genetic variant in the ACACB gene shows strong association with diabetic kidney disease in type 2 diabetes patients across multiple populations. Meta-analysis confirmed the link to proteinuria in Japanese patients and end-stage renal disease in European Americans. Lab studies revealed this variant enhances gene activity in kidney cells, suggesting a functional role in disease development.

Why Brain? 🧠

Genetic variant in ACACB gene strongly predicts kidney disease risk in type 2 diabetes patients across multiple populations, offering potential for early screening and personalized treatment strategies.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.