Authors: Zhen Zhang, Anca Selariu, Charles Warden, Grace Huang, Ying Huang, Oluleke Zaccheus, Tong Cheng, Ningshao Xia, Hua Zhu
DOI: 10.1371/journal.ppat.1000971
Abstract Summary
Researchers created a comprehensive library of varicella zoster virus mutants, systematically deleting each of its 70 genes to map their functions. They identified 44 essential genes for viral replication and discovered four genes—including the previously unknown ORF7—specifically required for skin infection but not cell culture growth, revealing potential therapeutic targets for chickenpox and shingles.
Why Brain? 🧠
Study creates comprehensive VZV gene library, identifying ORF7 as a new skin-specific replication factor, advancing understanding of chickenpox and shingles mechanisms for better vaccines and treatments.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
